#Does silver sulfadiazine cream expire skin

#Does silver sulfadiazine cream expire skin

As Burnsil can cause maceration of normal skin on prolonged contact, care should be taken to prevent spread on the non-ulcerated areas. Leg ulcers/pressure sores: The cavity of ulcer should be filled with Burnsil to a depth of at least 3-5 mm. The dressing should be changed when an excessive amount of exudate has accumulated in the bag. The patient should be encouraged to move the hand and fingers. Hand burns: Apply Burnsil to the burn area and enclose with a clean plastic bag or glove upto wrist. In burns, Burnsil should be re-applied at least every 24 hours, or more frequently if the volume of exudate is large. Where necessary, the cream should be re-applied to any area from which it has been removed by patient activity. This application is best achieved with a sterile gloved hand and/or a sterile spatula. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.īurns: Keep the burn wound in clean condition and apply Burnsil over the affected area to a depth of 3 to 5 mm. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. Silver binds to surface membranes and proteins, causing proton leaks in the membrane, leading to cell death. Silver ions bind to nucleophilic amino acids, as well as sulfhydryl, amino, imidazole, phosphate, and carboxyl groups in proteins, causing protein denaturation and enzyme inhibition. Silver is a biocide, which binds to a broad range of targets. A specific mechanism of action has not been determined, but silver sulfadiazine's effectiveness may possibly be from a synergistic interaction, or the action of each component. Silver sulfadiazine acts only on the cell membrane and cell wall to produce its bactericidal effect. Studies utilizing radioactive micronized silver sulfadiazine, electron microscopy, and biochemical techniques have revealed that the mechanism of action of silver sulfadiazine on bacteria differs from silver nitrate and sodium sulfadiazine.

Silver Sulfadiazine is also used to associated treatment for these conditions: Wound Infections This effect is very important in view of the fact that systemic antibiotics are not effective against the bacterial flora of vascular burn necrosis.

Silver Sulfadiazine penetrates into the necrotic tissue and exudate. It is also an effective agent against Candida albicans and other fungi. Silver Sulfadiazine cream has a broad antibacterial spectrum including virtually all microbial species likely to infect the burn wound: Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, strains of Proteus and Klebsiella. Silver ions bind to bacterial Deoxyribonucleic acid (DNA), thus inhibiting the growth and multiplication of bacterial cells without affecting the cells of the skin and subcutaneous tissue. Silver Sulphadiazine disintegrates in the burn wound, thereby causing a slow and sustained release of silver ions. Silver Sulphadiazine is a local chemotherapeutic agent for prevention and treatment of burn wound infections. Prophylaxis and treatment of infection in burn wounds-Īs an adjunct to short-term treatment of infection inĪs an adjunct to prophylaxis of infection inĬonservative management of Finger-tip injuries